International Conference onStem Cells, Regenerative Medicine and Tissue Engineering

Title: Autologous adipose-derived mesenchymal stem cell therapy reverses detrusor underactivity: Open clinical trial Deanna

Abstract:

Background Detrusor underactivity is a disease that can cause chronic urinary tract infection, urinary tract infec‑ tion, urinary retention and kidney failure and has no eective treatment in traditional medicine. The present research evaluated the eects of cell therapy with adipose tissue‑derived stem cells on the treatment of detrusor underactivity in men. Methods Nine male patients diagnosed with a clinical and urodynamic diagnosis of detrusor underactivity were evaluated and underwent two transplants via cystourethroscopy, with 2 × 106 cells/transplant, performed by intra‑ vesical injection at ve points on the bladder body above the vesical trigone. Results Cell therapy increased the maximum ow from 7.22 ± 1.58 to 13.56 ± 1.17, increased the mean ow from 3.44 ± 0.74 to 5.89 ± 0.45, increased the urinated volume from 183.67 ± 49.28 to 304.78 ± 40.42 and reduced the residual volume in the uroowmetry exam from 420.00 ± 191.41 to 118.33 ± 85.51; all of these changes were sig‑ nicant (p < 0.05). There were also signicant increases (p < 0.05) in maximum ow (from 7.78 ± 0.76 to 11.56 ± 1.67), maximum detrusor pressure (from 20.22 ± 8.29 to 41.56 ± 5.75), urinary volume (from 244 ± 27.6 to 418.89 ± 32.73) and bladder contractility index (from 44.33 ± 4.85 to 100.56 ± 8.89) in the pressure ow study. Scores on the International Consultation on Incontinence Questionnaire decreased from 11.44 ± 1.43 to 3.78 ± 0.78 after cell therapy, which indicates an improvement in quality of life and a return to daily activities. No complications were observed in the 6‑month follow‑up after cell therapy. Before treatment, all patients performed approximately ve intermittent clean catheterizations daily. After cell therapy, 7/9 patients (77.78%) did not need catheterizations and the number of catheterizations for 2/9 patients (22.28%) was reduced to two catheterizations/day. Conclusions The results indicate that stem cell therapy led to improvements in voiding function. Cell therapy with adipose tissue‑derived stem cells is safe and should be considered a new therapeutic option for the treatment of detrusor under activity.

Biography:

He holds a degree in Medicine from the Federal University of Grande Dourados (2006), a master's degree in Health and Development in the Midwest Region from the Federal University of Mato Grosso do Sul (2016) and a PhD in Health and Development in the Midwest Region from the Federal University of Mato Grosso do Sul (2022). He is currently a cooperative physician - Unimed Campo Grande MS - Medical Work Cooperative and urology service at the Maria Aparecida Pedrossian University Hospital. He has experience in the areas of urology, lithiasis, voiding dysfunction, oncology, and quality of life.